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It's a welcome new treatment for Canadians with Crohn's disease," said Dr. Brian G. Feagan *, M.D., Senior Scientific Officer, Robarts Clinical Trials Inc., Western University , London, Ontario , and UNITI study investigator. The Health Canada approval of STELARA is based on three pivotal Phase 3 studies (UNITI-1, UNITI-2 and IM-UNITI), recently published in the New England Journal of Medicine.6 The studies included more than 1,300 patients who were either new to, experienced with, or failed on biologic therapy (TNF blockers). The studies showed patients responding earlier to therapy, with some seeing noticeable improvement as early as three weeks,7 and others entering remission from their symptoms in six weeks after the start of therapy (34 per cent vs. 21.5 per cent in the placebo group in the UNITI-1 study and 56 per cent vs. 28.7 per cent in the placebo group in the UNITI-2 study).8 Additionally, the majority of those who responded to induction dosing and continued treatment with STELARA subcutaneous maintenance doses every eight weeks were in remission at the end of 44 weeks (52 weeks from initiation of the induction dose).9 "Crohn's disease is a lifelong condition that can impact a person's quality of life significantly," says Mina Mawani , President and Chief Executive Officer, Crohn's and Colitis Canada. "The introduction of a new therapy is an important advancement in treating patients, as the treatment offers an alternate method to induce and maintain remission. With one of the highest rates of Crohn's disease in the world, it's important that Canadians have access to new treatment options because not all therapies will work for everyone living with this inflammatory bowel disease." "Crohn's disease has no cure and patients living with this disease are in need of effective medications today.

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